NANOMEDICINE AND GENE-BASED THERAPEUTIC STRATEGIES FOR NEURODEGENERATIVE DISEASES: A COMPREHENSIVE REVIEW
Authors: Ajeet Singh, Megha Mishra, Kalyani Bokde, Dr. Ashish Chourasia, Sejal Haldker, Kartik Agrawal, Dr. Manju Pandey
Publication Date: 2026/03/25
DOI: 10.59551/DOI: 10.59551/IJHMP/25832069/2026.7.1.106
Abstract
<p>Parkinson disease is a highly progressive condition that affects working of brain. it damages substantia nigra a nerve, which contains dopamine producing neurons. The damage leads to tremors, rigidity, slowing of movements, stiffness in body and problems in posture. Current treatments approches on to manage symptoms. They include medications, therapies and surgeries. These treatments may result in fluctuating symptoms, side effects and disease progression The authors reviewed the developing field of nanomedicine as a hopeful option for the treatment of Parkinson’s disease. They highlighted its ability to address the weakness of traditional therapies. Nanomedicine uses nanoparticles for specific drug delivery these tiny particles are small enough to cross the blood brain barrier and deliver treatments directly to the affected areas in the brain. There are different types of nanoparticles such as lipids- based, polymeric, metallic, and carbon- based have shown promise for treating parkinsion’s disease. Additionally, systems like liposomes, nanogels, dendrimers, and solid lipid nanoparticles can provide controlled and extended release for treatments. The improves their effectiveness and reduce side effects The review offer all insights into parkinson’s disease explaining the root Causes of neuron (nerve) damage, the role of alpha – synuclein, and the disruption of dopamine pathways. It also discusses how gene therapy can be used as with nano medicine for better results.</p>
<p>KEYWORDS: Nanomedicine, Nanoparticles, Neuron, Neurodegenerative Disorder, Parkinson’s Disease.</p>
References
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