CD 57 EXPRESSION IN ORAL SQUAMOUS CELL CARCINOMA: A CLINICOPATHOLOGICAL AND PROGNOSTIC INSIGHT
Authors: Dr Jatin Yadav, Dr Alok Mohan, Dr Jyotishna Shukla, Dr Anupam Varshney*
Publication Date: 2026/08/18
DOI: 10.59551/DOI: 10.59551/IJHMP/25832069/2026.7.2.134
Abstract
<p>Background: Tumor microenvironment (TME) plays a critical role in tumor progression, via tumor-infiltrating immune cells. The role of CD57+ cells within the TME has been investigated in oral squamous cell carcinomas as a prognostic biomarker. The present study was done to evaluate the immunohistochemical expression of CD57 in oral squamous cell carcinoma and its correlation with histological grade and clinicopathological parameters.</p>
<p>Methods: A hospital-based descriptive study was conducted on 75 cases of OSCC received a tertiary teaching hospital in western Uttar Pradesh. The expression of CD57was assessed using immunohistochemistry and correlated with various clinicopathological parameters. </p>
<p>Results: The age of patients ranged from 30 to 80 years with a mean age of 51.44 ± 11.64 years. Males predominated (85.3%; male-to-female ratio 5.8:1). Buccal mucosa was the most common site (41.3%). Histologically, moderately differentiated tumours constituted the majority (53.3%), followed by well differentiated (34.7%) and poorly differentiated (12.0%). Overall, CD57 positivity was observed in 86.67% of cases. A statistically significant association was found between CD57 expression and histological grade (χ² = 17.30, df = 6, p = 0.0083). The mean CD57 positivity score was significantly higher in well differentiated tumours (7.83 ± 2.74) compared to moderately differentiated (5.10 ± 2.46) and poorly differentiated tumours (1.98 ± 1.38) (p < 0.001).</p>
<p>Conclusion: CD57 expression demonstrates a significant inverse correlation with histological grade in OSCC. These findings supported the potential role of CD57 as a biomarker for tumour differentiation status and possibly patient prognosis in OSCC.</p>
<p>KEYWORDS: CD57, Histological Grading, Immunohistochemistry, Natural Killer Cells, Oral Squamous Cell Carcinoma. </p>
References
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