Domperidone is a widely used antiemetic and prokinetic drug, but its poor water solubility and extensive first-pass metabolism limit its bioavailability and onset of action. This review focuses on the development of Domperidone rapid dissolving tablets (RDTs) as an effective strategy to overcome these challenges. Various formulation techniques such as direct compression, wet granulation, freeze drying, melt granulation, and sublimation are discussed, along with suitable excipients like super disintegrants, binders, and fillers. The review also highlights evaluation parameters including disintegration time, dissolution rate, hardness, moisture content, and stability. RDTs offer faster drug release, improved bioavailability, and enhanced patient compliance, especially among pediatric, geriatric, and dysphagic populations. The article provides insights for researchers to develop efficient, patient-friendly dosage forms.

Keywords: Domperidone, Rapid Dissolving Tablets (RDTs), Formulation Techniques, Bioavailability Enhancement, Disintegration and Dissolution Studies.